PhD Student (f/d/m)
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wanted as soon as possible at the Institute of Pharmacology at Heidelberg University's Faculty of Medicine.
In the department of Prof. Marc Freichel, Ca2+ signaling pathways in cellular and integrative organ functions are investigated. The main focus lies on TRP and Ca2+ channels in the plasma membrane as well as in acidic organelles such as endo-lysosomes and their role in Ca2+-dependent signal transduction and gene programs, with an emphasis on cells of the cardiovascular system (cardiomyocytes, cardiac fibroblasts, macrophages, platelets, chromaffin cells) and the processes they regulate, including contractility and metabolism, neurotransmitter secretion, and activation of the autonomic nervous system. The laboratory has longstanding expertise in transgenic approaches including genome editing, in cell (ES, iPS) and animal models, as well as AAV vector technologies, which are employed for generating disease models, identifying new drug targets, and validating small-molecule compounds.
The advertised PhD position is embedded in a project investigating a newly identified transmembrane protein in endo-lysosomes of cardiomyocytes. The focus is on its role in the regulation of arrhythmias and cardiac metabolism, which critically contribute to the development of cardiomyopathies. The project involves molecular and cellular experimental approaches to characterize the functional properties of the protein and to analyze its relevance for pathophysiological processes in the heart, and is integrated into several collaborative research networks (German Centre for Cardiovascular Research DZHK, TR-SFB 152, SFB 1550).
- Job-ID: V000015122
- Field of application: Pharmakologisches Institut
- Location: Heidelberg
- Job Category: Science and teaching
- Working hours: Part time
- Published: 05.12.2025
- Limitation:Temporary (3-4 years)
- Contract:TV-L
Your Profile
We are looking for highly motivated graduates in the life sciences including biochemistry and pharmacy with an interest in independent scientific work, self-motivation and the ability to work in a team and knowledge or previous experience in one or more of the following areas:
- Isolation/ culture/ characterization of primary cell systems, FACS, histology
- Fluorescence microscopy, electrophysiology Molecular biology and biochemical methods, performance and bioinformatics analysis of gene expression using OMICs approaches, metabolome, proteome, or secretome analyses, respectively
- Performing animal studies with disease models
- Very good knowledge of English
What we offer
- A friendly and collegial working atmosphere and a very diversified activity
- The opportunity for independent and team-oriented work
- Goal-oriented, individual training and further education opportunities in the above-mentioned techniques, research areas as well as in pharmacology and drug development (if applicable, further education to become a specialist pharmacologist of the DGPT)
- Targeted initial training
- Remuneration in accordance with TV-L E13 (collective agreement)
- Job ticket
- Possibility of child care (crèche and kindergarten) as well as subsidy for vacation care for school children
- Active health promotion
- Company pension plan
- Access to the university library and other university facilities (e.g. university sports)
Contact & Application
Are you interested?
Then we look forward to receiving your application by e-mail by 08. January 2026.
Pharmakologisches Institut
Prof. Dr. Marc Freichel
Im Neuenheimer Feld 366
69120 Heidelberg
office-AGFreichel@pharma.uni-heidelberg.de
Note: The UKHD is subject to the provisions of the Infektionsschutzgesetz. Therefore, a valid measles immunity certificate is required for all persons employed at the UKHD.
The UKHD embraces diversity and values diversity.
Regardless of age, gender, sexual identity, disability, origin or religion, we offer everyone the same opportunities. If one gender is underrepresented in a particular area, we place particular emphasis on counteracting this imbalance. If they have the same aptitude, qualifications and professional performance, we give priority to people with severe disabilities when considering them for vacancies.
Classification is based on qualifications and personal requirements. The salary (gross) is for a full-time position and does not include the annual bonus or other allowances.
